Pantopaque - General Information

A mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization. Pantopaque is a myelographic oil-ester (U.S. Patent 2,348,231). Pantopaque, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors. It next appeared on the world scene for high volume (12-15cc), routine use, in diagnosing disc herniations. A number of clinicians have published on the dangers of oil myelography. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Pantopaque as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected".


Pharmacology of Pantopaque

Pantopaque is a myelographic oil-ester initially introduced for use in small amounts (1-2cc) for locating spinal tumors. Later, it was found to cause adhesive arachnoiditis. Because these substances are hyperbaric once they were placed in the subarachnoid space they would migrate to the distal portion, where they remained, producing progressive scarring.


Additional information about Pantopaque

Pantopaque Indication: Used to locate spinal tumors
Mechanism Of Action: Pantopaque has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec (Radiology. 1986 Feb;158(2):457-60).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Iophendylate
Synonyms: Not Available
Drug Category: Contrast Media
Drug Type: Small Molecule; Approved

Other Brand Names containing Iophendylate: Pantopaque;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Pantopaque: Not Available
Chemical IUPAC Name: ethyl 10-(2-iodophenyl)undecanoate
Chemical Formula: C19H29IO2
Iophendylate on Wikipedia: Not Available
Organisms Affected: Humans and other mammals