Pathorysin - General Information
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Pharmacology of Pathorysin
Pathorysin, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Pathorysin is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis. Pathorysin is also a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex a.c. involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles.
Pathorysin for patients
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
PARAFON FORTE DSC chlorzoxazone is contraindicated in patients with known intolerance to the drug.
Additional information about Pathorysin
Pathorysin Indication: For the relief of discomfort associated with acute painful musculoskeletal conditions.
Mechanism Of Action: Pathorysin inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Pathorysin also may reduce the release of inflammatory leukotrienes. Pathorysin may act by inhibiting calcium influx.
Drug Interactions: Disulfiram Disulfiram increases chlorzoxazone levels
Food Interactions: Take without regard to meals.
Generic Name: Chlorzoxazone
Synonyms: Chloroxazone; Chlorzoxazon; Chlorzoxane
Drug Category: Muscle Relaxants, Central
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Oral, mouse: LD50 = 440 mg/kg; Oral, rat: LD50 = 763 mg/kg; Symptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting.
Protein Binding: 13-18%
Biotransformation: Chlorzoxazone is rapidly metabolized in the liver and is excreted in the urine, primarily in a conjugated form as the glucuronide.
Half Life: Not Available
Dosage Forms of Pathorysin: Capsule Oral
Chemical IUPAC Name: 5-chloro-3H-1,3-benzoxazol-2-one
Chemical Formula: C7H4ClNO2
Chlorzoxazone on Wikipedia: https://en.wikipedia.org/wiki/Chlorzoxazone
Organisms Affected: Humans and other mammals