Pbz-Sr - General Information

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Pbz-Sr is administered by various routes, including topically. [PubChem]


Pharmacology of Pbz-Sr

Used to treat the effects of colds and allergies. Pbz-Sr is an antihistamine. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Pbz-Sr is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.


Pbz-Sr for patients

Take with food, water, or milk to minimize gastric irritation. Swallow the extended-release dosage form whole (do not crush). If you miss a dose, take as soon as possible but do not take if it is almost time for your next dose. DO NOT double up on doses. Notify your doctor if skin tests using allergens is required as this medication may interfere with test results. Avoid use of alcohol or other CNS depressants while taking this medication. This medication can cause drowsiness or dizziness. Use caution while taking this medicine when driving or using equipment. Talk to your doctor if you are taking appetite suppressants. This medication can cause insomnia. Take the medication a few hours before bedtime if this occurs. This medication can cause dryness of mouth - use sugarless gum, candy, ice, or saliva substitute for relief. Check with your dentist if dry mouth continues for more than 2 weeks.


Pbz-Sr Interactions

Tripelennamine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).


Pbz-Sr Contraindications

Contraindicated in the following: blood disease, heart or blood vessel disease (may cause more serious conditions to develop), enlarged prostate, urinary tract blockage or difficult urination (phenothiazine-derivative antihistamines may cause urinary problems to become worse), epilepsy (phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the chance of seizures), glaucoma (may cause a slight increase in inner eye pressure that may worsen the condition, jaundice (phenothiazine-derivative antihistamines may make the condition worse), liver disease (phenothiazine-derivative antihistamines may build up in the body, which may increase the chance of side effects such as muscle spasms), Reye's syndrome (phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the chance of uncontrolled movements).


Additional information about Pbz-Sr

Pbz-Sr Indication: Used for the symptomatic relief of hypersensitivity reactions, coughs, and the common cold.
Mechanism Of Action: Pbz-Sr binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Tripelennamine
Synonyms: Not Available
Drug Category: Anti-Allergic Agents; Ethylenediamine Derivatives; Histamine H1 Antagonists
Drug Type: Small Molecule; Approved

Other Brand Names containing Tripelennamine: Benzoxale; Cizaron; Dehistin; PBZ; Pbz-Sr; Piribenzil; Pyribenzamin; Pyribenzamine; Pyridbenzamine; Pyrinamine Base; Resistamine; Tonaril; Tripelannamine; Tripelenamine; Tripelennamin; Tripelennamina; Tripelennamine Hcl; Tripellenamine; Triplennamine;
Absorption: Well absorbed in the digestive tract.
Toxicity (Overdose): Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands and trouble in sleeping.
Protein Binding: Not Available
Biotransformation: Hepatic
Half Life: Not Available
Dosage Forms of Pbz-Sr: Cream Topical
Chemical IUPAC Name: N',N'-dimethyl-N-(phenylmethyl)-N-pyridin-2-ylethane-1,2-diamine
Chemical Formula: C16H21N3
Tripelennamine on Wikipedia:
Organisms Affected: Humans and other mammals