Penthrane - General Information
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
Pharmacology of Penthrane
Penthrane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Additional information about Penthrane
Penthrane Indication: For use in the induction and maintenance of general anesthesia
Mechanism Of Action: Penthrane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Penthrane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Penthrane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Methoxyflurane
Synonyms: Not Available
Drug Category: Anesthetics, Inhalation
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
Protein Binding: Not Available
Half Life: Not Available
Dosage Forms of Penthrane: Not Available
Chemical IUPAC Name: 2,2-dichloro-1,1-difluoro-1-methoxyethane
Chemical Formula: C3H4Cl2F2O
Methoxyflurane on Wikipedia: https://en.wikipedia.org/wiki/Methoxyflurane
Organisms Affected: Humans and other mammals