Permiltin - General Information
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Permiltin also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Pharmacology of Permiltin
Permiltin, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Permiltin is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.
Permiltin for patients
This medicine is sometimes called a "blood thinner". This medicine prevents blood clots form forming and may be given following a stroke or heart attack or for patient who have an irregular heart beat.
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider.
Proper use of this medicine
Take this medicine exactly as directed. Do not take more or less of this medicine than prescribed. Your doctor may change the dosage of this medicine. Keep all lab appointments.
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.
Possible Side Effects
Check with your doctor as soon as possible if you experience any of the following:
- excessive bleeding from cuts
- bleeding from your gums
- excessive bruising
- discoloration of urine or stools
- black tarry stools
No pharmacokinetic drug-drug interaction studies were conducted with PERSANTINE® (dipyridamole USP) Tablets. The following information was obtained from the literature.
Adenosine: Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary.
Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.
Hypersensitivity to dipyridamole and any of the other components.
Additional information about Permiltin
Permiltin Indication: For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.
Mechanism Of Action: Permiltin likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Permiltin also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.
Drug Interactions: Adenosine Increases the effect/toxicity of adenosine
Fludarabine Decreases the effect of fludarabine
Food Interactions: Take with food to reduce irritation.
Coffee and tea can decrease the effect of dipyridamole.
Generic Name: Dipyridamole
Synonyms: Dipyridamol; Dipyridamine; Dypyridamol; Dipyudamine; Usaf Ge-12; Dipiridamol
Drug Category: Vasodilator Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Dipyridamole: Aggrenox; Agilease; Anginal; Apo-Dipyridamole Fc; Apo-Dipyridamole Sc; Apricor; Cardioflux; Cardoxil; Chilcolan; Cleridium; Cleridium 150; Coribon; Coridil; Coronarine; Corosan; Coroxin; Curantyl; Dipyridan; Gulliostin; IV Persantine; Justpertin; Kurantil; Natyl; Novo-Dipiradol; Peridamol; Permiltin; Persantin; Persantine; Piroan; Prandiol; Prandiol 75; Protangix; RA 8; RA-8; Stenocardil; Stenocardiol; Stimolcardio;
Toxicity (Overdose): Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD50 in rats is greater than 6,000 mg/kg while in the dogs, the oral LD50 is approximately 400 mg/kg. LD50=8.4g/kg (orally in rat)
Protein Binding: 99%
Half Life: 40 minutes
Dosage Forms of Permiltin: Solution Intravenous
Chemical IUPAC Name: 2-[[2-(bis(2-hydroxyethyl)amino)-4,8-di(piperidin-1-yl)pyrimido[6,5-e]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
Chemical Formula: C24H40N8O4
Dipyridamole on Wikipedia: https://en.wikipedia.org/wiki/Dipyridamole
Organisms Affected: Humans and other mammals