Promerane - General Information
Promerane is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.
Pharmacology of Promerane
Promerane is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.
Additional information about Promerane
Promerane Indication: Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
Mechanism Of Action: Promerane most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na+ ion, Cl- ion and water into the cells, without interfering with the active extrusion of Na+ ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Chlormerodrin
Synonyms: Not Available
Drug Category: Mercurial Diuretics; Diagnostic aids
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Promerane: Not Available
Chemical IUPAC Name: [3-(carbamoylamino)-2-methoxypropyl]-chloromercury
Chemical Formula: C5H11ClHgN2O2
Chlormerodrin on Wikipedia: Not Available
Organisms Affected: Humans and other mammals