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Propionylpromethazine

Propionylpromethazine - General Information

Propionylpromethazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.

 

Pharmacology of Propionylpromethazine

Propionylpromethazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.

 

Additional information about Propionylpromethazine

Propionylpromethazine Indication: Used to produce sleepiness or drowsiness and to relieve anxiety before or during surgery or certain procedures. Also used with analgesics during labor to produce drowsiness and relieve anxiety.
Mechanism Of Action: Propionylpromethazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Propionylpromethazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Propionylpromethazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Propiomazine
Synonyms: Not Available
Drug Category: Sedatives and Hypnotics
Drug Type: Small Molecule; Approved

Other Brand Names containing Propiomazine: Largon; Phenoctyl; Propiomazina [Inn-Spanish]; Propiomazine [Usan-Ban-Inn]; Propiomazinum [Inn-Latin]; Propionylpromethazine;
Absorption: Not Available
Toxicity (Overdose): Rare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness.
Protein Binding: 81%
Biotransformation: Unknown, but most likely hepatic as with other phenothiazines.
Half Life: Not Available
Dosage Forms of Propionylpromethazine: Not Available
Chemical IUPAC Name: 1-[10-(2-dimethylaminopropyl)phenothiazin-2-yl]propan-1-one
Chemical Formula: C20H24N2OS
Propiomazine on Wikipedia: https://en.wikipedia.org/wiki/Propiomazine
Organisms Affected: Humans and other mammals