Protivar - General Information
A synthetic hormone with anabolic and androgenic properties. [PubChem]
Pharmacology of Protivar
Protivar is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone.
Protivar for patients
Anabolic steroids may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may have to be decreased in order to maintain desired prothrombin time. Patients receiving oral anticoagulant therapy require close monitoring, especially when anabolic steroids are started or stopped.
Warfarin: A multidose study of oxandrolone, given as 5 or 10 mg BID in 15 healthy subjects concurrently treated with warfarin, resulted in a mean increase in S-warfarin half-life from 26 to 48 hours and AUC from 4.55 to 12.08 ng*hr/mL: similar increases in R-warfarin half-life and AUC were also detected. Microscopic hematuria (9/15) and gingival bleeding (1/15) were also observed. A 5.5-fold decrease in the mean warfarin dose from 6.13 mg/day to 1.13 mg/day (approximately 80-85% reduction of warfarin dose), was necessary to maintain a target INR of 1.5. When oxandrolone therapy is initiated in a patient already receiving treatment with warfarin, the INR or prothrombin time (PT) should be monitored closely and the dose of warfarin adjusted as necessary until a stable target INR or PT has been achieved.
Furthermore, in patients receiving both drugs, careful monitoring of the INR or PT, and adjustment of the warfarin dosage if indicated are recommended when the oxandrolone dose is changed or discontinued. Patients should be closely monitored for signs and symptoms of occult bleeding.
Oral hypoglycemic agents
Oxandrolone may inhibit the metabolism of oral hypoglycemic agents.
Adrenal steroids or ACTH
In patients with edema, concomitant administration with adrenal cortical steroids or ACTH may increase the edema.
Drug/Laboratory test interactions
Anabolic steroids may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged. In addition, a decrease in PBI and radioactive iodine uptake may occur.
- Known or suspected carcinoma of the prostate or the male breast.
- Carcinoma of the breast in females with hypercalcemia (androgenic anabolic steroids may stimulate osteolytic bone resorption).
- Pregnancy, because of possible masculinization of the fetus. Oxandrin has been shown to cause embryotoxicity, fetotoxicity, infertility, and masculinization of female animal offspring when given in doses 9 times the human dose.
- Nephrosis, the nephrotic phase of nephritis.
Additional information about Protivar
Protivar Indication: Use to promote weight gain after weight loss following extensive surgery.
Mechanism Of Action: Protivars interact with androgen receptors in target tissues.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Oxandrolone
Synonyms: Ossandrolone [DCIT]; Oxandrolona [INN-Spanish]; Oxandrolonum [INN-Latin]
Drug Category: Anabolic Agents; Androgens
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Oxandrolone: Anavar; Lonavar; Oxandrin; Protivar; Provitar; Vasorome;
Absorption: Not Available
Toxicity (Overdose): The oral LD50 of oxandrolone in mice and dogs is greater than 5,000 mg/kg.
Protein Binding: Not Available
Half Life: 0.55 hours (1st phage), 9 hours (2nd phase)
Dosage Forms of Protivar: Tablet Oral
Chemical IUPAC Name: (1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[7,6-h]isochromen-7-one
Chemical Formula: C19H30O3
Oxandrolone on Wikipedia: https://en.wikipedia.org/wiki/Oxandrolone
Organisms Affected: Humans and other mammals