Raunormin - General Information

Raunormin is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior.


Pharmacology of Raunormin

Raunormin, an alkaloid of Rauwolfia canescens, is used as an antihypertensive. Rauwolfia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure.


Raunormin for patients


Raunormin Interactions

Taking a rauwolfia alkaloid while you are taking or within 2 weeks of taking MAO inhibitors may increase the risk of central nervous system depression or may cause a severe high blood pressure reaction.


Raunormin Contraindications

Contraindicated in ulcerative colitis (rauwolfia alkaloids increase activity of the stomach, which may make the condition worse), heart disease, (rauwolfia alkaloids can cause heart rhythm problems or slow heartbeat), kidney disease (some patients may not do well when blood pressure is lowered by rauwolfia alkaloids), mental depression (rauwolfia alkaloids cause mental depression), and Parkinson's disease (rauwolfia alkaloids can cause parkinsonism-like effects).


Additional information about Raunormin

Raunormin Indication: For the treatment of hypertension.
Mechanism Of Action: Raunormin binds to and inhibits the angiotensin converting enzyme. Raunormin competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Deserpidine
Synonyms: Deserpidina [INN-Spanish]; Deserpidinum [INN-Latin]; Deserpidin; Desepridine; Deresperine; Deserpine; Desmethoxyreserpine
Drug Category: Antihypertensive Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Deserpidine: Aescin; Canescin; Canescine; Enduronyl; Harmonyl; Raunorine; Raunormin; Raunormine; Recanescin; Recanescine; Reserpidine; Tranquinil; beta-Escin;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include dizziness or drowsiness (severe), flushing of skin, pinpoint pupils of eyes and slowed pulse.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Raunormin: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C32H38N2O8
Deserpidine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals