Renormax - General Information

Renormax is an ACE inhibitor antihypertensive drug used to treat hypertension. Like many ACE inhibitors, this is a prodrug which is converted to the active metabolite spiraprilat following oral administration. ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure.


Pharmacology of Renormax

Renormax is an angiotensin-converting enzyme (ACE) inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. By blocking ACE, spirapril decreases angiotensin II which is a vasoconstrictor.


Additional information about Renormax

Renormax Indication: Used to treat hypertension.
Mechanism Of Action: Renormaxat, the active metabolite of spirapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Renormaxat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.
Drug Interactions: Not Available
Food Interactions: Avoid alcohol.
Avoid salt substitutes containing potassium.
Avoid natural licorice.
Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
Generic Name: Spirapril
Synonyms: Not Available
Drug Category: Antihypertensive Agents; Angiotensin-converting Enzyme Inhibitors
Drug Type: Small Molecule; Approved

Other Brand Names containing Spirapril: Renormax;
Absorption: Bioavailability is 50% following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic. Converted to spiraprilat following oral administration.
Half Life: 30 to 35 hours
Dosage Forms of Renormax: Not Available
Chemical IUPAC Name: (7S)-8-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-8-azaspiro[4.4]nonane-7-carboxylic acid
Chemical Formula: C22H30N2O5S2
Spirapril on Wikipedia:
Organisms Affected: Humans and other mammals