Rondomycin - General Information

A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period. [PubChem]


Pharmacology of Rondomycin

Rondomycin, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Rondomycin is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections.


Additional information about Rondomycin

Rondomycin Indication: For the treatment of acute bacterial exacerbations of chronic bronchitis
Mechanism Of Action: Rondomycin is first metabolized to 14-OH Rondomycin. Like other macrolides, it then binds to the 50 S subunit of the 70 S ribosome of the bacteria, blocking RNA-mediated bacterial protein synthesis. Rondomycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Methacycline
Synonyms: Metacycline; Methacyclin
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Methacycline: Rondomycin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Rondomycin: Not Available
Chemical IUPAC Name: (2Z,4S,4aR,5S,5aR,12aS)-2-(amino-hydroxymethylidene)-4-dimethylamino-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
Chemical Formula: C22H22N2O8
Methacycline on Wikipedia:
Organisms Affected: Enteric bacteria and other eubacteria